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Patients with a history of kidney stones should be vigilant about their fluid intake. Meeting the American Urological Associations recommended urine output of 2.5 liters per day generally requires around 96 ounces, or 3 liters, of daily fluid intake

This is one of the simplest things you can do to protect your protocol and one of the most commonly skipped steps

Phase I is facilitated by cytochrome P450 enzymes that modulate various biotransformation reactions, making lipophilic toxic substances more hydrophilic

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Journal of the Endocrine Society, 6 , A509