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Cycle Duration and Monitoring Typical cycle: 1224 weeks Monitoring: baseline and 1012 week IGF-1 measurement is the most common biomarker Washout: 48 weeks between cycles is standard practitioner practice Contraindications Active malignancy GH/IGF-1 axis elevation is a theoretical oncogenic concern Diabetes mellitus GH elevates insulin resistance

Then, a May 2025 NEJM head-to-head study comparing tirzepatide with semaglutide confirmed that Mounjaro led to greater mean weight loss and waist reduction over 72 weeks

There are currently no reports of Ozempic interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD)

This suggests that the proportion of patients with long-term use of the medications is larger than indicated by analyses that focus on treatment discontinuation

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