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It is acknowledged that the stimulation of signal transducers and activators of transcription 3 (STAT3) is essential for the transformation into the M2 subtype, whereas the activation of STAT1 is a crucial determinant for the M1 subtype [85]
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10.1007/s00125-011-2440-x
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However, results across all studies are inconsistent and generally modest [3]
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