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Side effects documented in pediatric populations include nausea, vomiting, and gastrointestinal discomfort similar to adult experiences, though the frequency and severity in developing bodies is still being characterized

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A2A receptor activation upregulates vascular endothelial growth factor (VEGF), promotes angiogenesis in dermal microvasculature, stimulates fibroblast migration and proliferation, and suppresses inflammatory cytokine release

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