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According to NICE guidance on type 2 diabetes management (NG28), treatment should be individualised, and medications causing intolerable side effects should be reviewed
Most quit breakthrough weight-loss drug within a year Date: September 14, 2025 Source: European Association for the Study of Diabetes Summary: A massive Danish study reveals that despite the remarkable weight-loss benefits of semaglutide, more than half of adults without diabetes stop using it within a year
History of alcohol use disorder: The reduced alcohol cravings observed with GLP-1 medications may feel like a benefit but patients with AUD should discuss any alcohol use with their physician or addiction specialist rather than relying on a pharmacological side effect as their primary support
Each step up in dosage produced approximately 3 additional percentage points of weight loss: 1mg (8.7%), 4mg (15.2%), 8mg (21.1%), and 12mg (24.2%)