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However, berberine is not approved as a pharmaceutical drug in most countries and lacks the decades of safety and efficacy data that metformin carries

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Epithalon has been extensively evaluated in aging-prone and cancer-prone rodent models, where it has been shown to reduce spontaneous tumor formation, suppress oncogene expression (notably HER-2/neu), and increase median and maximal lifespan 1,2

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found in some OTC cosmetics Off-label use discussed here: wound healing (topical and injectable) Evidence level: preclinical strong, human clinical limited (GRADE equivalent: very low to low) Key mechanism: upregulates collagen I/III, VEGF, decorin, and anti-inflammatory cytokines Typical compounded concentration: 0.01% to 1% topical