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Fasano, a world-renowned gastroenterologist, in order for autoimmunity to be triggered, three factors must be present (this is referred to as the three-legged stool of autoimmunity): [1] A genetic predisposition Intestinal permeability/leaky gut A triggering event or root cause factor Each of these three legs or factors plays its own role in triggering autoimmunity (explained throughout this article)

Discovery of a selective and orally bioavailable FGFR2 degrader for treating gastric cancer

Evidence increasingly supports an elevated risk associated with persistent, intensive NSW, particularly when initiated early in life or combined with genetic susceptibility