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Front Immunol (2019) 10:639

A coherent mechanistic rationale is not the same as demonstrated synergy, and animal-model effect sizes do not translate cleanly to human dosing

A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair