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In RPE cells, iron overload downregulates the expression of circSPECC1 and Rpe65, which disrupts RPE cells polarity, induces ultrastructural abnormalities and atrophy, and activates microglia

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Thus, we suggest that after 14 days of the ageing of apple seeds, NOx application stimulates GR and GPX-like activities and probably promotes the further conversion of GSH, which, however, requires verification

Miyamoto S, Kollman PA (1992) Settle: an analytical version of the SHAKE and RATTLE algorithm for rigid water models