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Combining retatrutide with insulin or sulfonylureas significantly increases the risk of hypoglycaemia and may require dose adjustments

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Some people use twice daily dosing and still get good results

Ruth Loos, a genetic epidemiologist at the University of Copenhagen, who was not involved in the study, noted that the extra weight loss, on average, may not seem like a lot, but that for those with two copies of the GLP1R variant, it was more than 10 percent of the total weight loss that people experienced in the study population

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