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Interestingly, PICs were shown to induce the expression of heme oxygenase-1 (HO-1), which promotes the release of free Fe 2+ into the cytoplasm and subsequently an increased mitochondrial accumulation of iron in cultured glial cells (76), thus contributing to increased generation of mitochondrial ROS

It is estimated that approximately 3040% of the cells zinc is located in the nucleus, whereas the remainder is distributed across the cytosol, organelles, specific vesicles and, to a lesser extent, associated with cell membranes 29

Research suggests that VLEKT has therapeutic potential in treating HS symptoms, particularly through its anti-inflammatory effects, reduction of body fat, and changes in the gut microbiota composition, which modulate systemic inflammation and oxidative stress (216)

Vitamin B5 (Pantothenic Acid) is a component of coenzyme A

Glutathione plays a crucial role in the detoxification processes, managing oxidative stress that can impact overall health