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Very rare (may affect up to 1 in 10,000 people): Non-arteritic anterior ischaemic optic neuropathy (NAION) a medical condition of the eye which may cause loss of vision in one eye without pain

This work further highlights how physiologically relevant in vitro systems are becoming a mechanistic backbone for predicting oral bioavailability, improving translational relevance, and supporting the development of next-generation therapeutics

Notably, the US FDA submission documents for tirzepatide include predictions of DDIs mediated by delayed gastric emptying using PBPK modeling, rather than conducting clinical DDI studies for certain drugs (Table 6)

100 mg (5%*)