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Approximately 2.2 million bone grafts are performed globally each year, ranking as the second most common tissue transplantation after blood transfusion (Sivakumar et al., 2022)

In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)