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The rats received doses of KBP-089 (KBP) (0.625, 1.25 and 2.5 g/kg sc), liraglutide (L) (200 and 400 g/kg sc) and the combinations (KBP 0.625 + L 200 g/kg, KBP 0.625 + L 400 g/kg, KBP 1.25 + L 200 g/kg, KBP 1.25 + L 400 g/kg and KBP 2.5 + L 200 g/kg, KBP 2.5 + L 400 g/kg) and vehicle (saline) for 9 weeks

Its important to understand the difference between medically proven facts and research versus hype and TikTok trends

The American College of Rheumatology guidelines emphasize weight loss as a core non-pharmacological intervention for overweight and obese patients with knee osteoarthritis, with evidence supporting that even modest weight reduction (5-10% of body weight) can produce clinically meaningful improvements in pain and function

Heitzer, B

doi: 10.1016/j.jclinepi.2022.04.017 298