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Phase IIB and IIA pharmacologic agents Key Point Only a small proportion of pharmacologic treatments evaluated in phase II progress to phase III and even fewer progress to market

These include changes in the size and pigmentation of moles, rapid appearance of new moles, facial flushing, abdominal cramps, nausea, vomiting, chest pain and brain swelling

This leads to: Improved skin firmness and elasticity Reduction in fine lines and wrinkles Enhanced dermal thickness 2

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But identifying who might be at higher risk allows for more informed decision-making and earlier recognition if symptoms develop