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To address affordability, Eli Lilly introduced LillyDirect on December 1, 2025, offering lower-cost single-dose vials of Zepbound

It can also be used in individuals who are overweight (body mass index of 27 kg/m2 or greater) with at least one weight-related risk factor such as Type 2 diabetes, high blood pressure, or high cholesterol

Patients using insulin or other glucose-lowering medications may require dose adjustments to prevent low blood sugar episodes

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Expert Perspective To better understand these patterns, we asked Alessandro Grenci, Superintendent Pharmacist at Medino , for his view