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For instance, during the early phases of acute myocardial infarction, the acute onset of high-grade local inflammation is revealed not only by the polymorphonuclear neutrophils activation and recruitment of mononuclear cells but also by the local release of pro-inflammatory molecules such as IL-1 and IL-6 [118]

Research indicates that oral L-citrulline supplementation produces more efficient nitric oxide synthesis by bypassing first-pass hepatic metabolism that typically degrades L-arginine before it can reach target tissues [2]

doi: 10.1046/j.1526-4610.2003.03006.x 17

The 2024 Inflammopharmacology review compiled the most current GI-protection data set across more than two decades of research

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