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Cathepsin L regulates oocyte meiosis and preimplantation embryo development

Nat Rev Endocrinol (2026)

In 17 patients with type 2 diabetes maintained on diet therapy alone who consumed a standard meal (372 kcal, 49% carbohydrate, 40% fat, 11% protein), a single dose of acarbose 100mg significantly attenuated the postprandial rise of prothrombin fragments 1 and 2 (2.0 vs 2.7 mmol/L at 2 hours) and D-dimer (2.85 vs 3.50 g/L at 1 hour) compared with placebo

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