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GLP-1 receptor agonists: Exploration of transformation from metabolic regulation to multi-organ therapy

Drugs 15 , 190 (2017)

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More recent semaglutide data suggest improvements in sperm morphology and testosterone while preserving normal gonadotropin signaling. Philip Werthman, MD One of the most important clinical distinctions is that GLP-1 therapies appear fundamentally different from testosterone replacement therapy for men who wish to preserve fertility, he noted

Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD (2014) Quantitative flux analysis reveals folate-dependent NADPH production