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Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically
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Thats an enormous number of people that are being missed. Metabolic health experts at L-Nutra, the science-driven company behind Prolon, explain why chronic calorie restriction often backfires and how time-bound metabolic interventions are reshaping the future of sustainable weight loss
A 2025 review characterized retatrutide's up-to-24% weight loss at 48 weeks as a step-change versus prior incretin therapies [6]
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