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Targeted supplements: Data indicates that calorie intake reduces by 16-39% while taking a GLP1 medication (Spreckley 2026)

Treating Sarcopenic Obesity in the Era of Incretin Therapies: Perspectives and Challenges

But the fundamental mechanisms are the same

Semaglutide users who took a weekly dose of 2.4 mg for 68 weeks, or roughly 15 months, dropped an average of 35 pounds, or 15% of their body weight, compared to 2.4% for the placebo group

Compared to diet alone, in the group of 342 newly diagnosed overweight patients with T2DM treated with metformin, MI was reduced by 39%, coronary deaths by 50%, stroke by 41%, and all-cause mortality by 36% after a median 10.7 years (14)