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Furthermore, the autophagy enhancer rapamycin inhibits the mTOR pathway, upregulates the expression of LC3- and Beclin-1, triggers autophagy, facilitates the aggregation of PMF, and improves the survival rate of oocytes (Sun et al., 2018)

Together, these results suggest that the complement system, particularly C4A, may play a key role in the gene-environment interactions of schizophrenia by modulating the gut microbiota and systemic immune activation status

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