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Use over-the-counter itch creams (preferably with hydrocortisone)

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2025;31:e70440

In the animal model of sarcopenic obesity (SO), activating the AMPK/PINK1/Parkin-mediated mitophagy pathway can effectively regulate glucolipid metabolism and improve skeletal muscle atrophy, thereby repairing the mitochondrial structure and function in muscle tissue [46]

The pivotal SURPASS clinical trial program evaluated tirzepatide in various combinations, including with metformin