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As such, the observed rise in call volume likely reflects a combination of rapid expansion in the user base and variable degrees of stimulated reporting

[3] Initial dosing for moderate vasomotor symptoms typically ranges from 1 mg to 5 mg intramuscularly every three to four weeks, with some clinicians favoring a midpoint 2.5 mg monthly regimen and titrating upward or downward according to symptom relief and serum estradiol targets

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It was originally isolated from human plasma in 1973 and has since become one of the most widely researched copper peptides in published scientific literature