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Prioritizing lifestyle interventions remains fundamental

Because renal TECs are highly metabolically active and heavily rely on mitochondrial oxidative phosphorylation, they are vulnerable to cuproptosis-mediated damage (215)

These reactions appear rare based on the overall review distribution but warrant mention

9 Importantly, the key enzyme of GSH synthesis, gamma-glutamyl-cysteinyl-synthetase, is already active by the 2nd trimester of pregnancy, suggesting enzymatic immaturity is unlikely to be a primary limiting factor