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The NHS Diabetes Prevention Programme offers evidence-based support for individuals with non-diabetic hyperglycaemia (prediabetes)
Maladaptive repair of TECs leads to the transformation of injured TECs into a secretory phenotype and elicits proinflammatory (e.g., interleukin, tumor necrosis factor, and chemokine) [42,43,44]and profibrotic cytokines [45] (e.g., TGF- and CTGF)
Based on these results, in January 2025 the FDA approved Ozempic for a new indication : reducing the risk of kidney disease worsening, kidney failure, and cardiovascular death in adults with type 2 diabetes and CKD
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