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But if the question extends to energy homeostasis, feeding behavior, or the interplay between GH and metabolic state, that appetite signal becomes the most valuable variable in the study

Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

However, we recognize that each individual is unique

Shedding light on the effects of calorie restriction and its mimetics on skin biology