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Both drugs prevented MPTP-induced motor impairment, protected dopaminergic neurons in the substantia nigra, reduced the expression of the proapoptotic signaling molecule Bax, and increased the levels of the antiapoptotic molecule Bcl-2 [87]

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Mechanism-based comparisons are helpful, but outcome-based evidence, safety data, and formulation quality matter more than marketing categories [2], [11]

Khuloud Al-Jamal, Professor of Drug Delivery and Nanomedicine from Kings College London, said: Not only did the gel perform better than a simple solution, but the brain uptake was better than that achieved using intravenous injection of the drug

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