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Gweyer, Wragg, Wilson
The STEP TEENS trial (N=201, ages 12, 17) demonstrated that semaglutide 2.4 mg once weekly reduced BMI by 16.1% versus a 0.6% increase with placebo at 68 weeks [11]
This usually subsides within minutes and decreases with continued use
It regulates enzymes like sirtuins and PARPs, which are involved in cellular aging, inflammation, and stress response
Bull Exp Biol Med 2002;133:4946
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