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The downregulation of OCTN2 activity and protein expression in the kidney reduces the reabsorption of carnitine in the kidney, leading to a decrease in carnitine availability in the liver and causing hepatic lipid metabolism disorders [260]

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In 2008, this lab reported that an additional complex RAS synthetic lethal 3 (RSL3) induced a similar cell death form, which could be inhibited by iron chelates (Yang and Stockwell, 2008)

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