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Furthermore, the gastrointestinal tract also has a major role in metformin action through modulation of glucose-lowering hormone glucagon-like peptide 1 and the intestinal bile acid pool and alterations in gut microbiota composition
Retrieved April 8, 2023
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The disbalance between the inhibited enterocytic influx and unchanged or increased systemic demand may cause specific vulnerability of the gut epithelium to toxic effects of the thiamine-competitive drugs targeting SLC19A3
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