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Adding semaglutide to retatrutide would duplicate GLP-1 receptor activation, which could increase side effects without proportionally increasing efficacy
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However, current data from SEMA clinical trials indicate that therapeutic effects on liver fibrosis are unclear, with potential benefits possibly involving the delay of fibrosis progression
TennCare has covered GLP-1 precursors and their counterparts since they became FDA approved in 2005 as add-on therapy for diabetes management, and cardiovascular disease mid-year 2024, consistent with federal requirements and TennCare Medical Necessity Rules
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