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When a drug is in short supply, as is the case with Ozempic and Wegovy, compounders can create an altered version of the drug if they meet certain requirements in the Federal Food, Drug, and Cosmetic Act

Increased release of glutamate from presynaptic terminals activates N -methyl-D-aspartate (NMDA) receptors on postsynaptic terminals to lead to a widespread neuronal depolarization or spreading depression, further disrupting the sodium ion, potassium ion, and calcium ion equilibria (Langlois et al., 2006)

This includes nausea (feeling like youre going to throw up) or pain

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