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NPCs incubated with different concentrations of GSH-CDs for 30 min were then cocultured with H 2 O 2 (100 M) or PBS for 24 h

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3.1.1 Impact of ROS on cellular function and atherosclerosis Elevated ROS can induce endothelial cell dysfunction or death, disrupting the vascular barrier and leading to vasoconstrictive and vasodilatory dysfunction, vascular smooth muscle cell proliferation and migration, inflammatory responses, and thrombosisprocesses intimately associated with various cardiovascular disorders, including atherosclerosis, hypertension, and CHD (31)

This lead discovery demonstrates that squaryl entities are a powerful tool in the intellectual property of pharmaceuticals (Figure 44)