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found that irisin-mediated p53 reduction decreases ferroptosis and protects cardiomyocytes against high-glucose injury by increasing SIRT1, decreasing p53 K382 acetylation to promote p53 degradation, and consequently upregulating SLC7A11 and GPX4 [108]

Medications like Ozempic, Wegovy, and Rybelsus work by mimicking the hormone that helps regulate blood sugar levels and appetite

Once absorbed, intracellular esterases remove the acetyl group to release free glutathione

The most common side effects include bloating, nausea, and diarrhea

Patients may experience appetite changes within a few weeks, but it can take several months before significant changes in weight are noticeable