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Description

Semaglutide targets the GLP-1 pathway, while tirzepatide works on two pathways (GLP-1 and GIP)

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The first and second main components explain 72.26% of the total variance, with the first principal component representing 56.46% and the second principal component representing 15.80% of the total variance

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Such widespread usage has led to a severe and prolonged international shortage of these drugs 13,14 , with consequent lack of access to treatment for patients with diabetes 15 and the urgent need to issue guidelines for alternative treatments 16

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