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Some researchers hypothesize that maintaining adequate NAD+ levels might support the metabolic improvements initiated by tirzepatide, potentially enhancing insulin sensitivity or supporting weight loss efforts
What is the safety of long-term usage
When food intake drops further on GLP1s, total nutrient intake can fall below requirements even if weight loss is on track. In a large US database study of 461,382 adults on GLP1 medications, 12.7% were newly diagnosed with a nutritional deficiency by 6 months and 22% by 12 months, with vitamin D deficiency most common
After confirming a normal distribution and homogeneous variances, we assessed efficacy in the two groups using Students t-test for quantitative variables
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