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Clinical Preparation and Handling Before Injection Before administering Retatrutide, healthcare professionals follow a structured preparation process

The cold temperature helps to slow down chemical reactions, reducing the rate of peptide degradation and preserving its therapeutic activity

In some cases, temporary dose reduction or pausing dose escalation of the GLP-1 medication may be appropriate while nutritional status is optimized, though this decision should be made collaboratively between patient and provider

Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD et al

Although cotadutide has progressed well through clinical trials, other GLP-1/glucagon co-agonists have shown mixed results