If the pain starts quickly, lasts longer than a few days, worsens instead of improving, or makes it hard to raise or use your arm, it could be a sign of something more serious than typical injection irritation
Quite often though, a patient with B12 deficiency experiences symptoms getting worse before better when treatment with B12 injections start -so it can take a while to feel improvements
Collagen organization matters as much as collagen quantity
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Most patients notice increased energy within 1-2 weeks