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Since superoxide anion cannot diffuse across the inner mitochondrial membrane it remains in the matrix which allows it to react with Fe-S groups in mitochondrial proteins resulting in the liberation of ferrous (Fe 2+ ) iron

It has been proposed that a reduced GST activity in these individuals would slow the rate of excretion of isothiocyanates, thereby increasing tissue exposure to isothiocyanates after cruciferous vegetable consumption (55)

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The compounds could potentially be combined, as their mechanisms do not overlap