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J Clin Med 11:3859

GHK-Cu operates through fibroblast gene expression modulation and copper-dependent enzyme activation, a fundamentally distinct cellular mechanism acting on a different cell population

Working with fibroblast cultures, they demonstrated that GHK-Cu stimulated collagen synthesis at concentrations beginning between 10 picomolar and 100 picomolar, with peak stimulation at 1 nanomolar

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The figure 25.3 % surpasses: Tirzepatide SURMOUNT-1: 22.5 % Semaglutide STEP-1: 14.9 % Retatrutide Phase 2: 24.2 % (comparable, but Phase 3 results for Retatrutide are still lacking) It raises the question whether CagriSema will be the first molecule with an effect truly comparable to bariatric surgery (typically 2530 % reduction)