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Zepbound targets two hormone receptors (GLP-1 and GIP), while Wegovy targets just one, which is part of why the two medications don't always produce identical results
So despite being more effective, tirzepatide was actually better tolerated in this trial
Ipamorelin is a pentapeptide ghrelin mimetic that acts on the GHSR1a receptor, selectively stimulating GH secretion without significantly affecting cortisol, prolactin, or ACTH [4] [7]
Mazahir et al
Compared to the native hormones, retatrutide shows 2.9-fold less potency at the glucagon receptor (GCCR), 2.5-fold less potency at the GLP-1 receptor, and 8.9-fold greater potency at human GIP receptor [1]
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