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As a biguanide , metformin can also lower vitamin B12 levels over time, so clinicians often monitor for vitamin B12 deficiency during long-term use
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At the end of six weeks, those in the Dunaliella group showed reductions in their PASI scores compared with the placebo group, and these results were sustained at 12 weeks
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Furthermore, results from a phase II clinical trial conducted on AD patients demonstrated that NR administration was associated with favorable alterations in cerebrospinal fluid biomarkers indicative of improved mitochondrial function [23]
