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Finally, restrain-free production run was carried out for each simulation, with a time step of 2 fs in the NPT ensemble at 310 K and 1 bar using the Nose-Hoover thermostat and the semi-isotropic Parrinello-Rahman barostat 68 , respectively
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Drinking plenty of water will help with fatigue and flush out water weight, so you see results faster on the scale
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