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The stumbling block has always been that it has to be given IV, in a clinic licensed for administration of intravenous drugs, in order to be effective

Given these biological and methodological constraints, the field is increasingly turning toward multimodal strategies to capture the complexity of neuroprotection

At the time of these studies, the roles of reactive oxygen species (ROS) in cells were poorly characterised and information on subcellular compartmentation was at best fragmentary

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