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However, because this enzyme sits at the top of the mevalonate pathway, statins simultaneously block the downstream production of endogenous Geranylgeraniol (GG)

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It has decades of randomized controlled trial data behind it and is widely regarded as the reference-standard topical retinoid against which newer molecules are measured

The drug is approved to treat Type 2 diabetes and has weight loss as a prominent side effect, so it's often prescribed off-label for this reason

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