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In this PCOS model of gestational androgenization, treatment with GLP1/GIP improved glucose handling, fasting glucose levels and insulin sensitivity, as denoted by ITT and HOMA-IR, as well as circulating insulin concentrations (Fig

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These effects were tumor-cell specific: TVB-3166 suppressed anchorage-independent growth under lipid-rich culture conditions and significantly inhibited xenograft tumor growth in vivo , at concentrations aligned with its biochemical IC 50 for FASN and palmitate synthesis (255)

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