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In recent years, continued improvements in sequencing and imaging technologies have broadened the scope of spatial omics

Since the GHSR system also modulates other physiological functions such as GH secretion, it is necessary to expand understanding of the pathways involved and develop biased ligands to modulate only the therapeutically relevant signaling pathway (127)

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The best pharmacophore model was developed with eight DPP-4 inhibitors, featuring one hydrogen bond donor (HBD), one hydrogen bond acceptor, and two hydrophobic characteristics