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JAMA 331 , 3848 (2024)

Possessing stem-like properties, tumor-repopulating cells (TRCs) develop therapeutic resistance to both chemotherapy and irradiation through mechanisms that reduce their susceptibility to ferroptotic cell death (81)

Highdose vitamin C infusions are sometimes used as adjunct therapy in cancer treatment or to combat infections, but they may become prooxidative at very high concentrations and should only be administered by qualified professionals

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