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In immature human dendritic cells, progesterone increased expression of mitochondrial complex II-V genes (succinate dehydrogenase complex iron sulfur subunit B, [SDHB], succinate dehydrogenase complex subunit C [SDHC], ubiquinol-cytochrome C reductase complex III subunit VII [UQCRQ], cytochrome c oxidase subunit II [COX II], and ATP synthase F1 subunit alpha [ATP5A]), and mitochondrial pyruvate carrier 1 (MPC1) (194)
New blood vessel growth could theoretically support tumor growth
That pattern is consistent with prescribing information describing gastrointestinal adverse reactions during escalation
Generally, escalation is considered when patients fail to achieve glycemic targets or experience weight loss plateaus
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